LC-MS for RNA Therapeutics to Ensure Product Quality and Process Consistency
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LC-MS for RNA Therapeutics to Ensure Product Quality and Process Consistency
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41:21
LC-MS for RNA Therapeutics to Ensure Product Quality and Process Consistency
Mass spec is a reliable tool for oligonucleotide quality control. We show techniques on the BioAccord LC-MS System and Vion IMS QTof System to confirm the sequence of RNA and DNA oligo therapeutics covering adjuvant, siRNA, ASO, sgRNA and aptamers.
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Join world-renowned Professor Perdita Barran from the Institute of Biotechnology as she shares her incredible research into Parkinson's Disease.
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Multiple Attribute Monitoring (MAM) is a method used to concurrently analyze various critical quality attributes (CQAs) of biotherapeutics.
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Clone selection, early in the development lifecycle, has an outsize impact on the ability to match the quality target product profile (QTPP) for a given product.
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Resolution performance of LC and MS techniques is challenged by development of long therapeutic oligonucleotides such sgRNA. We'll discuss the application of a modern method LC for separation and MS characterization of long oligonucleotides.
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This presentation comprehensively covers the opportunities and challenges related to the adoption of the MAM method across the entire spectrum, ranging from R&D to commercial QC for the release and stability testing of biotherapeutics.
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