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Chromatographic Techniques for the Characterization of CQAs in Biosimilars
Critical to the development and commercialization of a biosimilar is understanding the originator and how its CQAs compare against those of the biosimilar. Learn more about our solutions that provide high quality peptide mapping, glycan and charge va
1:03:24
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Advancing Technology for Better Medicine with MaxPeak HPS Technology
Learn how to improve assay robustness and reduce the burden associated with migrating methods downstream in the analysis and monitoring of product quality attributes of biopharmaceuticals.
41:25
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Robust Multi-Level LC-MS Workflows for Biosimilar Comparability Assessment
Watch this presentation to learn about the uses of the Xevo G3 QTof mass spectrometer in a case study of biosimilar mAb characterization at intact, subunit, and peptide level.
48:24
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Automated LC-MS Workflow for CQA Assessment of Protein Therapeutics with Speed and Simplicity for Process Development
Here we demonstrate how sample prep has been greatly simplified and automated to enable rapid LC-MS (intact and subunit) analysis at higher throughput, with less human intervention, all while providing high quality to support process development.
1:01:40
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Metabolomics Profiling of Sebum and Serum to Monitor Progression Markers of Parkinson's Disease
Join world-renowned Professor Perdita Barran from the Institute of Biotechnology as she shares her incredible research into Parkinson's Disease.
22:49
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LC-MS for RNA Therapeutics to Ensure Product Quality and Process Consistency
LC-MS for RNA Therapeutics to Ensure Product Quality and Process Consistency
41:21
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Streamlined mAb Subunit LC-MS Workflow for Multiple Attribute Monitoring of Biosimilar mAb Candidates During Bioprocessing and Development
Clone selection, early in the development lifecycle, has an outsize impact on the ability to match the quality target product profile (QTPP) for a given product.
38:53
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Elevating Product Quality - BioAccord in Action Video
Released N-linked glycan analysis is the gold standard for N-glycan profiling of therapeutic monoclonal antibodies (mAbs) as they play an important role in safety and efficacy.
25:51
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Expedite Process Development with Automated PQA and Spent Media Analysis with the BioAccord LC-MS System
Here we show how an automation-assisted at-line LC-MS based Process Analytical Technology (PAT) has been successfully implemented to understand process parameters affecting the mis-paired bispecific antibody ratio.
43:22
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Multiple-Attribute Monitoring (MAM) at Peptide or Subunit Levels: Ready for QC
Multiple Attribute Monitoring (MAM) is a method used to concurrently analyze various critical quality attributes (CQAs) of biotherapeutics.
59:41
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MAM Deployment for QC Analytical Testing and Substitution of Conventional Analytical Methods
This presentation comprehensively covers the opportunities and challenges related to the adoption of the MAM method across the entire spectrum, ranging from R&D to commercial QC for the release and stability testing of biotherapeutics.
19:37
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Oligonucleotide Sequence Confirmation for Quality Control by Micheal Ruhl from BioSpring
Mass spec is a reliable tool for oligonucleotide quality control. We show techniques on the BioAccord LC-MS System and Vion IMS QTof System to confirm the sequence of RNA and DNA oligo therapeutics covering adjuvant, siRNA, ASO, sgRNA and aptamers.
21:09
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