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Oligonucleotide Sequence Confirmation for Quality Control by Micheal Ruhl from BioSpring
Mass spec is a reliable tool for oligonucleotide quality control. We show techniques on the BioAccord LC-MS System and Vion IMS QTof System to confirm the sequence of RNA and DNA oligo therapeutics covering adjuvant, siRNA, ASO, sgRNA and aptamers.
21:09
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LC MS Methods for Characterization of Long Oligonucleotides
Resolution performance of LC and MS techniques is challenged by development of long therapeutic oligonucleotides such sgRNA. We'll discuss the application of a modern method LC for separation and MS characterization of long oligonucleotides.
31:36
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Analytics to Ensure the Quality of Gene Therapy Products
Hear from Martin De Cecco, Ph.D. from BioReliance who discusses the important attributes of gene therapy products and the different analytical techniques that we have available to characterize them.
13:12
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WEBINAR | Oligonucleotide analysis From characterization to routine monitoring
Hear from Thomas De Vijlder from Janssen who discusses bridging the gap between advanced characterization and routine monitoring when it comes to mass spectrometry-based oligonucleotide analysis.
20:41
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WEBINAR | Complexities of Characterizing gRNAs for CRISPR Applications
Hear Steve Wolk from Editas Medicine who discusses challenges and approaches for longer oligonucleotides and describes the analysis of the CRISPR enzyme complex (RNP).
21:41
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WEBINAR | Advancing the Analysis of rAAV Viral Vectors using LC-MS Technologies
In this webinar, Ximo Zhang discusses the development of a series of LC/MS workflows for AAV analysis.
16:06
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WEBINAR | Enhancing LC-MS analysis of oligos, peptides, and glycans using hybrid surface technology
Waters scientists describe the benefits of the the ACQUITY Premier Solution with MaxPeak High Performance Surfaces Technology in mitigating problematic metal interactions to improve recovery, peak shape, and reproducibility of sensitive analytes.
1:00:47
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Improved LC-MS Analysis of Oligonucleotides with Next Generation Chromatography
In this webinar, Dr. Martin Gilar presents data that demonstrates the impact metal interactions have on oligo analysis and shows how ACQUITY Premier Oligonucleotide BEH C18 Columns with MaxPeak Technology eliminate the need for column conditioning.
47:27
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Webinar | Considerations for Developing IP-RP Methods for Oligonucleotide Analysis
Learn about method development considerations when selecting an appropriate ion-pairing agent and impurity analysis of dye-conjugated oligonucleotides.
26:25
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Webinar | Oligonucleotide Intact Mass Confirmation on the BioAccord System LC/MS System
Barbara Sullivan, Waters Biopharmaceutical Group Leader in the MS Applications Lab, gives an overview of the BioAccord System and demonstrates the molecular confirmation workflow using several different types of oligonucleotides.
16:32
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Advanced Detection and Separations for Oligonucleotides
This webinar provides discussions of reversed phase separations of oligonucleotides and the use of various analytical workflows and detection methods including high resolution mass spectrometry.
1:05:56
